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Destiny breast 03 publication

Sep 19,  · About DESTINY-Breast Fam-trastuzumab deruxtecan-nxki was approved by the U.S. Food and Drug Administration in December for the treatment of patients with . Recommendation based on DESTINY-Breast03 trial results showing AstraZeneca Results from DESTINY-Breast03 have been published in The New. Apr 1, The DESTINY-Breast03 study is an industry-sponsored, phase 3, multicenter randomized trial comparing T-DXd to T-DM1 in patients with  . Fam-trastuzumab deruxtecan-nxki (T-DXd) showed statistically significant improvement in progression-free survival vs trastuzumab emtansine (T-DM1) in second-line treatment for HER2-positive unresectable or metastatic breast cancer, according to results from the global phase III DESTINY-Breast03 trial, which was presented by Javier Cortés, MD, PhD, and colleagues at a Presidential. DESTINY Breast Second-Line Fam-Trastuzumab Deruxtecan-nxki for Metastatic HER2-Positive Breast Cancer. About DESTINY-Breast03 Fam-trastuzumab deruxtecan-nxki was approved by the U.S. Food and Drug Administration in December for the treatment of patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens, based on results from the phase II DESTINY-Breast01 trial. The DESTINY-Breast03 study, a randomized, phase III trial pitting the antibody-drug conjugates trastuzumab emtansine and trastuzumab deruxtecan against each other in HER2+ . Abstract. ENHERTU efficacy and safety evaluated in DESTINY-Breast03— a head-to-head Phase 3 clinical trial powered for PFS (BICR) · History of ILD/pneumonitis requiring.

  • Aug 9, DESTINY-Breast03 is a global head-to-head, randomised, open-label, registrational Phase III trial evaluating the safety and efficacy of Enhertu  .
    • In DESTINY-Breast 03, Trastuzumab Deruxtecan, a HER2-specific antibody-drug conjugate, proved superior to T-DM1 in patients with HER2+ metastatic breast cancer progressing on taxane and trastuzumab.1This study supported its recent approval as second-line therapy in HER2+ metastatic breast cancer. Abstract. In DESTINY-Breast 03, Trastuzumab Deruxtecan, a HER2-specific antibody-drug conjugate, proved superior to T-DM1 in patients with HER2+ metastatic breast cancer progressing on taxane and trastuzumab.1 This study supported its recent approval as second-line therapy in HER2+ metastatic breas . Jun 21,  · In DESTINY-Breast 03, Trastuzumab Deruxtecan, a HER2-specific antibody-drug conjugate, proved superior to T-DM1 in patients with HER2+ metastatic breast cancer . That is a randomized phase 3 study comparing efficacy and safety of trastuzumab deruxtecan. The DESTINY-Breast03 trial is even more impressive. By contrast, only one person  . Jul 5, In DESTINY-Breast04, 45 people in the T-DXd group (about 12%) developed this side effect, and 3 died as a result. The median duration of treatment was 14 months (range: to 30). DESTINY-Breast03 The safety of ENHERTU was evaluated in patients with unresectable or metastatic HER2-positive breast cancer who received at least one dose of ENHERTU mg/kg in DESTINY-Breast ENHERTU was administered by intravenous infusion once every three weeks. DOI: /CD-NB Abstract The DESTINY-Breast03 study, a randomized, phase III trial pitting the antibody-drug conjugates trastuzumab emtansine and trastuzumab deruxtecan against each other in HER2+ metastatic breast cancer, found remarkable improvements in efficacy and safety for the latter, newer therapy. Breast cancer remains the most common cancer and is one of the leading causes of cancer-related deaths in women worldwide.1 More than two million cases of breast cancer were . 5 Jul (T-DM1) in patients (Pts) with HER2+ metastatic breast cancer (mBC): Results of the randomized phase III DESTINY-Breast03 study | Find. Published Online: July 7th   . in breast cancer clinical trials – DESTINY-Breast04, DESTINY-Breast03, TROPiCS, CDK4/6 trial data, MAINTAIN study. Publication types. The DESTINY-Breast03 study, a randomized, phase III trial pitting the antibody-drug conjugates trastuzumab emtansine and trastuzumab deruxtecan against each other in HER2+ metastatic breast cancer, found remarkable improvements in efficacy and safety for the latter, newer therapy. © American Association for Cancer Research. Mark Pegram, MD: DESTINY-Breast03 is a phase III study investigating T-DXd [trastuzumab deruxtecan] versus T-DM1 [ado-trastuzumab emtansine] in patients previously treated with trastuzumab and a. treatment option for eligible patients with certain cancers, including . DESTINY Clinical Trials. A series of international trials investigating trastuzumab deruxtecan (T-DXd)* as a potential. Based on ground-breaking DESTINY-Breast03 results in which from the DESTINY-Breast03 Phase III trial, which were published in The New. For more information about the trial,  . Jul 19, Results from DESTINY-Breast03 have been published in The New England Journal of Medicine. Transcript: Komal Jhaveri, MD, FACP: Let me just quickly walk us through the DESTINY-[Breast]03 trial [NCT]; this was the very first randomized study of trastuzumab deruxtecan [T-DXd. Methods: We conducted a phase 3, multicenter, open-label, randomized trial to compare the efficacy and safety of trastuzumab. Background: Trastuzumab emtansine is the current standard treatment for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer whose disease progresses after treatment with a combination of anti-HER2 antibodies and a taxane. Trastuzumab Deruxtecan in HER2-Low Advanced Breast Cancer. Approximately 60% of human epidermal growth factor receptor 2 (HER2)–negative metastatic . QUICK TAKE. ASCO | DESTINY-Breast safety follow-up results In this updated safety analysis, T-DXd demonstrated a tolerable safety profile. Jul 19, Based on ground-breaking DESTINY-Breast03 results in which from the DESTINY-Breast03 Phase III trial, which were published in The New  . %). The incidence. The incidence of adverse events that resulted in the discontinuation of the trial treatment was higher with trastuzumab deruxtecan than with trastuzumab emtansine (% vs. The incidence. The incidence of adverse events that resulted in the discontinuation of the trial treatment was higher with trastuzumab deruxtecan than with trastuzumab emtansine (% vs. %). Jun 06,  · Dr. Modi indicated that 2 studies are currently ongoing, DESTINY-Breast06 (NCT) and DAISY (NCT), to determine the minimum IHC HER2 . DESTINY-Breast03 trial, fewer than 3% of the patients with HER2-positive disease who re- ceived trastuzumab deruxtecan had a decrease in. 7 Jul In the. Aug 5, That approval was based on a study also published in NEJM; The phase 3 DESTINY-Breast04 trial enrolled patients with metastatic  .
  • Select Cancer Type. DESTINY Clinical Trials A series of international trials investigating trastuzumab deruxtecan (T-DXd)* as a potential treatment option for eligible patients with certain cancers, including breast, gastric, lung, and additional cancer types. Select a cancer type to learn more about current clinical trials.
    • Trastuzumab Deruxtecan in HER2-Low Advanced Breast Cancer. Approximately 60% of human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancers express low. QUICK TAKE. In DESTINY-Breast 03, Trastuzumab Deruxtecan, a HER2-specific antibody-drug conjugate, colleagues published the first clinical. Apr 30, The published results of DESTINY-Breast03 (6) shows, compared with the traditional anti-HER2 ADC drug T-DM1, T-DXd has significant  . A series of international trials investigating trastuzumab deruxtecan (T-DXd)* as a potential. treatment option for eligible patients with certain cancers, including breast, gastric, lung, and. additional cancer types. Select a cancer type to learn more about current clinical trials. DESTINY Clinical Trials. Patients enrolled in the trial had prior lines of chemotherapy for metastatic disease. DESTINY-Breast04 is the first randomized clinical trial to show that targeting HER2 provides clinically meaningful benefits for patients with HER2-low metastatic breast cancer. 8 Agu In the DESTINY-Breast03 study, trastuzumab deruxtecan yielded an objective In summary, published data suggest that, despite their large. Patients enrolled in the trial had prior lines of chemotherapy for metastatic disease. Patients with hormone receptor–positive disease had to be refractory to endocrine therapy. DESTINY-Breast04 is the first randomized clinical trial to show that targeting HER2 provides clinically meaningful benefits for patients with HER2-low metastatic breast cancer. Interstitial lung disease and pneumonitis are important risks requiring careful monitoring and prompt intervention. Trastuzumab deruxtecan showed promising and durable activity in HER2-positive metastatic colorectal cancer refractory to standard treatment, with a safety profile consistent with that reported in previous trastuzumab deruxtecan trials.